Chelerythrine

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Chelerythrine

Product name: Chelerythrine
Plant source:
Toddalia asiatica (L.)Lam.
Molecular formula: C21H18ClNO4   
Molecular weight: 383.83
CAS: 34316-15-9   
Characteristics: light yellow powder or white powder, melting point: 195-205°C , 207℃(lmol ethanol) or 250℃(0.5mol water)
Specifications: 50%、90%、95%、98% HPLC
Product Description:
Potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.

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