Sibutramine

Product name : Sibutramine

CAS NO . :106650-56-0

Molecular formula : C12H26ClNHClH2O

Molecular Weight : 279.85

Property :
Sibutramine hydrochloride monohydrate is a white to off-white crystalline powder, or white cream crystalline powder, insoluble in water and soluble in grain alcohol .

Pharmacology :
It is an orally administered agent for treatment of obesity. It mainly becomes effective through the metabolin of its amine （secondary amine and primary amine）, its main mechanism is increasing the feeling of satiation by controlling the reingestion of noradrenalin, serotonin 5-HT and dopamine, however, it has no evident effect on the release of noradrenalin, serotonin 5-HT and dopamine. Studies also shows that, this product and its amine activated metabolin have no evident prohibiting effects, such as, choline-resisting, histamine-resisting, and monoamine oxidase. Sibutramine is the first new weight-lreducing drug approved by FDA with recently 30 years. Therefore, its curative effect is safe and stable, is the most mature weight-reducing aid. 

Usage:
Follow a reduced-calorie diet while taking sibutramine, as directed by your doctor. Sibutramine may be taken with or without food, on a full or empty stomach. However, if your doctor tells you to take it in a certain way, take it as directed.
Untoward reaction :
The common untoward reaction has: dry mouth, anorexia, insomnia and constipation. Other untoward reactions that its incidence rate is above 1% have: fever, heart rate increase, elevation of blood pressure, decompensation, diarrhea and gastroenteritis. This product may cause abnormal liver function, which usually vanished with farther treatment. 

Tabu :
1. The one who takes monoamine oxidase inhibitor.
  2.the one who takes anorectic medicines which works in nervus centralis
  3.The one who suffers from hysteric apepsia
  4. The one who is allergic to this product.
  5. high blood pressure suffer whose blood pressure is hard to control and can’t be 

Pharmacology :
It is an orally administered agent for treatment of obesity. It mainly becomes effective through the metabolin of its amine （secondary amine and primary amine）, its main mechanism is increasing the feeling of satiation by controlling the reingestion of noradrenalin, serotonin 5-HT and dopamine, however, it has no evident effect on the release of noradrenalin, serotonin 5-HT and dopamine. Studies also shows that, this product and its amine activated metabolin have no evident prohibiting effects, such as, choline-resisting, histamine-resisting, and monoamine oxidase. Sibutramine is the first new weight-lreducing drug approved by FDA with recently 30 years. Therefore, its curative effect is safe and stable, is the most mature weight-reducing aid.